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KMID : 1101320080400020071
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Korean Journal of Clinical Laboratory Science
2008 Volume.40 No. 2 p.71 ~ p.74
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A Cytogenetic Analysis of Abortus with Spontaneous Abortion
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Oh Hyun-Sook
Hwang Si-Mok
Kwon Kyung-Hun
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Abstract
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Chromosomal abnormalities of abortus have also been used to investigate the most common etiology of spontaneous abortion, but the frequency and the types of spontaneous abortions have also demonstrated considerable variation among in different countries and races. A cytogenetic analysis of 75 abortuses was performed at the GenDix, Inc. from January, 2006 to December, 2007. The frequency of chromosome abnormalities in abortus was 32.0% (24/75 cases). Among the chromosomal abnormalities, trisomy was 62.5% (15/24 cases) and the most frequent trisomy was trisomy 21 with 26.6% (4/15 cases). The average maternal age of normal and abnormal karyotypes was 34.1±3.3 and 34.3±3.3. Cytogenetic analysis of abortus is important for diagnosis and genetic counseling for parents with spontaneous abortion.
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KEYWORD
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Chromosome, Karyotype, Cytogenetic analysis of abovtus, Spontanous abortion
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